Phosphatidate phosphatase LPIN1

Definition:

Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels. Is involved in adipocyte differentiation (By similarity). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression (By similarity). Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).

References:

[1]. Gil-Soo Han, et al. Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms. J Biol Chem. 2010 May 7;285(19):14628-38. [Content Brief]

[2]. Terytty Yang Li, et al. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun. 2018 May 15;9(1):1916. [Content Brief]

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