Phosphatidylinositol transfer protein alpha isoform

Definition:

Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3.

References:

[1]. Sadaf Shadan, et al. Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells. Traffic. 2008 Sep;9(10):1743-56. [Content Brief]

[2]. Y Fullwood, et al. Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta. J Biol Chem. 1999 Oct 29;274(44):31553-8. [Content Brief]

[3]. Kathryn Garner, et al. Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid. J Biol Chem. 2012 Sep 14;287(38):32263-76. [Content Brief]

[4]. Sarah J Tilley, et al. Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol. Structure. 2004 Feb;12(2):317-26. [Content Brief]

[5]. Alan N Hunt, et al. Acyl chain-based molecular selectivity for HL60 cellular phosphatidylinositol and of phosphatidylcholine by phosphatidylinositol transfer protein alpha. Biochim Biophys Acta. 2004 Nov 8;1686(1-2):50-60. [Content Brief]

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