Photosensitizer (PS)

Definition:

Photosensitizer (PS) is usually encapsulated in nanoparticulate formulations (such as liposomes) and also can be chemically conjugated with various nanocarriers to improve their in vivo performance. PSs can be preferentially localized in malignant tissues, and when are activated with appropriate wavelength of light, they can pass on their excess energy to surrounding molecular oxygen, resulting in the generation of Reactive oxygen species (ROS) such as free radicals and singlet oxygen (O2), which are toxic to cells and tissues. PS can be used for Photodynamic therapy (PDT) of cancer.

References:

[1]. Ya-Xuan Zhu, et al. Photosensitizer (PS)/polyhedral oligomeric silsesquioxane (POSS)-crosslinked nanohybrids for enhanced imaging-guided photodynamic cancer therapy. Nanoscale. 2017 Sep 14;9(35):12874-12884. [Content Brief]

[2]. Tymish Y Ohulchanskyy, et al. Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer. Nano Lett. 2007 Sep;7(9):2835-42. [Content Brief]

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