Pilomatricoma

Definition:

Pilomatricoma is a benign cutaneous tumor of follicular structures. It occurs either in isolation or in conjunction with other symptoms such as myotonic dystrophy and Rubenstein-Taybi syndrome. The histologic appearance of the tumor is characterized by cells resembling those of the hair follicle matrix and sometimes show differentiation toward the follicular infundibulum and surrounding sheath.

References:

[1]. Alexander J F Lazar, et al. Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin. J Cutan Pathol. 2005 Feb;32(2):148-57. [Content Brief]

[2]. E F Chan, et al. A common human skin tumour is caused by activating mutations in beta-catenin. Nat Genet. 1999 Apr;21(4):410-3. [Content Brief]

[3]. H Tsao, et al. Genetics of nonmelanoma skin cancer. Arch Dermatol. 2001 Nov;137(11):1486-92. [Content Brief]

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