Pleckstrin homology domain-containing family N member 1

Definition:

Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells (By similarity).

References:

[1]. Akane Maeda, et al. Role of N-myristoylation in stability and subcellular localization of the CLPABP protein. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1249-1256. [Content Brief]

[2]. Etsuko Sano, et al. Novel tyrosine phosphorylated and cardiolipin-binding protein CLPABP functions as mitochondrial RNA granule. Biochim Biophys Acta. 2008 Jun;1783(6):1036-47. [Content Brief]

[3]. Sei Kuriyama, et al. PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. Cell Death Discov. 2018 Feb 8;4:11. [Content Brief]

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