Pleckstrin homology domain-containing family O member 1

Definition:

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

References:

[1]. Lingqiang Zhang, et al. CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM. Cell Signal. 2006 Sep;18(9):1386-95. [Content Brief]

[2]. Lingqiang Zhang, et al. Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis. EMBO J. 2005 Feb 23;24(4):766-78. [Content Brief]

[3]. David A Canton, et al. The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein. J Biol Chem. 2006 Nov 24;281(47):36347-59. [Content Brief]

[4]. Lingqiang Zhang, et al. The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. Cell Signal. 2007 May;19(5):932-44. [Content Brief]

[5]. Alexias Safi, et al. Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation. Mol Cell Biol. 2004 Feb;24(3):1245-55. [Content Brief]

[6]. Emi Tokuda, et al. Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo. Cancer Res. 2007 Oct 15;67(20):9666-76. [Content Brief]

[7]. David A Canton, et al. The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein. Mol Cell Biol. 2005 May;25(9):3519-34. [Content Brief]

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