Poly-ADP-ribosylation-amplifying and CtIP-maintaining micropeptide

Definition:

Micropeptide that acts as a regulator of DNA repair both by preventing KLHL15-mediated ubiquitination and degradation of RBBP8/CtIP, and by promoting the poly-ADP-ribosyltransferase activity of PARP1. Prevents KLHL15-mediated ubiquitination of RBBP8/CtIP by competitively blocking the association between KLHL15 and RBBP8/CtIP. Recruited to DNA damage sites via association with poly-ADP-ribose chains, and enhances the poly-ADP-ribosyltransferase activity of PARP1.

References:

[1]. Chuanchao Zhang, et al. Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation. Mol Cell. 2022 Apr 7;82(7):1297-1312.e8. [Content Brief]

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