Polyamine deacetylase HDAC10

Definition:

Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair.

References:

[1]. Yang Hai, et al. Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nat Commun. 2017 May 18;8:15368. [Content Brief]

[2]. Shweta Kotian, et al. Histone deacetylases 9 and 10 are required for homologous recombination. J Biol Chem. 2011 Mar 11;286(10):7722-7726. [Content Brief]

[3]. Ina Oehme, et al. Histone deacetylase 10 promotes autophagy-mediated cell survival. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2592-601. [Content Brief]

[4]. Hung-Ying Kao, et al. Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. J Biol Chem. 2002 Jan 4;277(1):187-93. [Content Brief]

[5]. Amaris R Guardiola, et al. Molecular cloning and characterization of a novel histone deacetylase HDAC10. J Biol Chem. 2002 Feb 1;277(5):3350-6. [Content Brief]

[6]. Denise D Fischer, et al. Isolation and characterization of a novel class II histone deacetylase, HDAC10. J Biol Chem. 2002 Feb 22;277(8):6656-66. [Content Brief]

[7]. Johannes Ridinger, et al. Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance. Sci Rep. 2018 Jul 3;8(1):10039. [Content Brief]

[8]. Jenny J Tong, et al. Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res. 2002 Mar 1;30(5):1114-23. [Content Brief]

[9]. Rangasudhagar Radhakrishnan, et al. Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2. J Biol Chem. 2015 Sep 11;290(37):22795-804. [Content Brief]

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