Polymerase delta-interacting protein 2

Definition:

Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites. May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1).

References:

[1]. Thomas A Guilliam, et al. PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities. Nucleic Acids Res. 2016 Apr 20;44(7):3317-29. [Content Brief]

[2]. Giovanni Maga, et al. DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18850-5. [Content Brief]

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