Potassium-transporting ATPase alpha chain 2

Definition:

The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment. Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance.

References:

[1]. N N Modyanov, et al. Human ATP1AL1 gene encodes a ouabain-sensitive H-K-ATPase. Am J Physiol. 1995 Oct;269(4 Pt 1):C992-7. [Content Brief]

[2]. Alison T Lennox, et al. ATP12A promotes mucus dysfunction during Type 2 airway inflammation. Sci Rep. 2018 Feb 1;8(1):2109. [Content Brief]

[3]. A V Grishin, et al. Functional expression of the cDNA encoded by the human ATP1AL1 gene. Am J Physiol. 1996 Sep;271(3 Pt 2):F539-51. [Content Brief]

[4]. G Adams, et al. Catalytic function of nongastric H,K-ATPase expressed in Sf-21 insect cells. Biochemistry. 2001 May 15;40(19):5765-76. [Content Brief]

[5]. A V Grishin, et al. ATP1AL1, a member of the non-gastric H,K-ATPase family, functions as a sodium pump. J Biol Chem. 1998 Oct 23;273(43):27772-8. [Content Brief]

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