POU domain class 2-associating factor 1

Definition:

Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity).

References:

[1]. M Gstaiger, et al. A B-cell coactivator of octamer-binding transcription factors. Nature. 1995 Jan 26;373(6512):360-2. [Content Brief]

[2]. Y Luo, et al. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol Cell Biol. 1995 Aug;15(8):4115-24. [Content Brief]

[3]. M Strubin, et al. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell. 1995 Feb 10;80(3):497-506. [Content Brief]

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