PR domain zinc finger protein 14

Definition:

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.

References:

[1]. Noriko Nishikawa, et al. Gene amplification and overexpression of PRDM14 in breast cancers. Cancer Res. 2007 Oct 15;67(20):9649-57. [Content Brief]

[2]. Na-Yu Chia, et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature. 2010 Nov 11;468(7321):316-20. [Content Brief]

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