Prenylcysteine oxidase 1

Definition:

Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded.

References:

[1]. W R Tschantz, et al. Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. J Biol Chem. 2001 Jan 26;276(4):2321-4. [Content Brief]

[2]. W R Tschantz, et al. Cloning, expression, and cellular localization of a human prenylcysteine lyase. J Biol Chem. 1999 Dec 10;274(50):35802-8. [Content Brief]

[3]. Jennifer A Digits, et al. Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase. J Biol Chem. 2002 Oct 25;277(43):41086-93. [Content Brief]

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