Probable cytosolic iron-sulfur protein assembly protein CIAO1

Definition:

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

References:

[1]. Shinsuke Ito, et al. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. Mol Cell. 2010 Aug 27;39(4):632-40. [Content Brief]

[2]. R W Johnstone, et al. Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1. J Biol Chem. 1998 May 1;273(18):10880-7. [Content Brief]

[3]. Vasundara Srinivasan, et al. Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis. Structure. 2007 Oct;15(10):1246-57. [Content Brief]

[4]. Oliver Stehling, et al. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. Cell Metab. 2013 Aug 6;18(2):187-98. [Content Brief]

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