Probable ribonuclease ZC3H12D

Definition:

May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages. Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation.

References:

[1]. Min Wang, et al. Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1. Cancer Res. 2007 Jan 1;67(1):93-9. [Content Brief]

[2]. Kentaro Minagawa, et al. Inhibition of G(1) to S phase progression by a novel zinc finger protein P58(TFL) at P-bodies. Mol Cancer Res. 2009 Jun;7(6):880-9. [Content Brief]

[3]. Shengping Huang, et al. Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation. J Biol Chem. 2015 Aug 21;290(34):20782-20792. [Content Brief]

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