Progesterone-induced-blocking factor 1

Definition:

Plays a role in ciliogenesis.; [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2.; [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect. Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein.

References:

[1]. J Szekeres-Bartho, et al. The mechanism of the inhibitory effect of progesterone on lymphocyte cytotoxicity: I. Progesterone-treated lymphocytes release a substance inhibiting cytotoxicity and prostaglandin synthesis. Am J Reprod Immunol Microbiol. 1985 Sep;9(1):15-8. [Content Brief]

[2]. J Szekeres-Bartho, et al. Progesterone as an immunomodulatory molecule. Int Immunopharmacol. 2001 Jun;1(6):1037-48. [Content Brief]

[3]. Noemi Kozma, et al. Progesterone-induced blocking factor activates STAT6 via binding to a novel IL-4 receptor. J Immunol. 2006 Jan 15;176(2):819-26. [Content Brief]

[4]. Kyeongmi Kim, et al. The pericentriolar satellite protein CEP90 is crucial for integrity of the mitotic spindle pole. J Cell Sci. 2011 Feb 1;124(Pt 3):338-47. [Content Brief]

[5]. Andrew Kodani, et al. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Elife. 2015 Aug 22;4:e07519. [Content Brief]

[6]. Beata Polgar, et al. Molecular cloning and immunologic characterization of a novel cDNA coding for progesterone-induced blocking factor. J Immunol. 2003 Dec 1;171(11):5956-63. [Content Brief]

[7]. Gabrielle Wheway, et al. An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nat Cell Biol. 2015 Aug;17(8):1074-1087. [Content Brief]

[8]. Kyeongmi Kim, et al. CEP90 is required for the assembly and centrosomal accumulation of centriolar satellites, which is essential for primary cilia formation. PLoS One. 2012;7(10):e48196. [Content Brief]

[9]. Gordana Laskarin, et al. Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity. Am J Reprod Immunol. 2002 Oct;48(4):201-9. [Content Brief]

[10]. Aliesha González-Arenas, et al. Progesterone-induced blocking factor is hormonally regulated in human astrocytoma cells, and increases their growth through the IL-4R/JAK1/STAT6 pathway. J Steroid Biochem Mol Biol. 2014 Oct;144 Pt B:463-70. [Content Brief]

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