Programmed cell death protein 10

Definition:

Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).

References:

[1]. Faraz K Mardakheh, et al. RHO binding to FAM65A regulates Golgi reorientation during cell migration. J Cell Sci. 2016 Dec 15;129(24):4466-4479. [Content Brief]

[2]. F Bergametti, et al. Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations. Am J Hum Genet. 2005 Jan;76(1):42-51. [Content Brief]

[3]. Miguel Fidalgo, et al. CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. J Cell Sci. 2010 Apr 15;123(Pt 8):1274-84. [Content Brief]

[4]. Xi Ma, et al. PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway. Mol Biol Cell. 2007 Jun;18(6):1965-78. [Content Brief]

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