Proline/serine-rich coiled-coil protein 1

Definition:

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.

References:

[1]. Seul Kim, et al. ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis. Biochem Biophys Res Commun. 2016 Feb 12;470(3):484-491. [Content Brief]

[2]. Chang-Young Jang, et al. DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. J Cell Biol. 2008 Apr 21;181(2):255-67. [Content Brief]

[3]. Chang-Young Jang, et al. The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3. Cell Cycle. 2009 Oct 1;8(19):3165-71. [Content Brief]

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