Proteasome activator complex subunit 3

Definition:

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition.

References:

[1]. S Wilk, et al. Properties of the nuclear proteasome activator PA28gamma (REGgamma). Arch Biochem Biophys. 2000 Nov 15;383(2):265-71. [Content Brief]

[2]. Martina Magni, et al. Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis. Nucleic Acids Res. 2014 Dec 1;42(21):13150-60. [Content Brief]

[3]. Zhuo Zhang, et al. Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation. EMBO J. 2008 Mar 19;27(6):852-64. [Content Brief]

[4]. C Realini, et al. Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators. J Biol Chem. 1997 Oct 10;272(41):25483-92. [Content Brief]

[5]. J Li, et al. Lysine 188 substitutions convert the pattern of proteasome activation by REGgamma to that of REGs alpha and beta. EMBO J. 2001 Jul 2;20(13):3359-69. [Content Brief]

[6]. Xiaolin Gao, et al. Purification procedures determine the proteasome activation properties of REG gamma (PA28 gamma). Arch Biochem Biophys. 2004 May 15;425(2):158-64. [Content Brief]

[7]. J Li, et al. The proteasome activator 11 S REG or PA28: chimeras implicate carboxyl-terminal sequences in oligomerization and proteasome binding but not in the activation of specific proteasome catalytic subunits. J Mol Biol. 2000 Jun 9;299(3):641-54. [Content Brief]

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