Proteasome adapter and scaffold protein ECM29

Definition:

Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis. Promotes proteasome dissociation under oxidative stress (By similarity).

References:

[1]. Carlos Gorbea, et al. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. J Biol Chem. 2010 Oct 8;285(41):31616-33. [Content Brief]

[2]. Carlos Gorbea, et al. Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles. J Biol Chem. 2004 Dec 24;279(52):54849-61. [Content Brief]

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