Protein BRICK1

Definition:

Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).

References:

[1]. Emmanuel Derivery, et al. Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. PLoS One. 2008 Jun 18;3(6):e2462. [Content Brief]

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