Protein FRG1

Definition:

Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B.

References:

[1]. S van Koningsbruggen, et al. FRG1P is localised in the nucleolus, Cajal bodies, and speckles. J Med Genet. 2004 Apr;41(4):e46. [Content Brief]

[2]. Melissa S Jurica, et al. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA. 2002 Apr;8(4):426-39. [Content Brief]

[3]. Maria Victoria Neguembor, et al. FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis. J Mol Cell Biol. 2013 Oct;5(5):294-307. [Content Brief]

[4]. Meredith L Hanel, et al. Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a dynamic nuclear and sarcomeric protein. Differentiation. 2011 Feb;81(2):107-18. [Content Brief]

[5]. Chia-Yun Jessica Sun, et al. Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein. J Mol Biol. 2011 Aug 12;411(2):397-416. [Content Brief]

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