Protein NDRG1

Definition:

Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.

References:

[1]. Susanne Stein, et al. NDRG1 is necessary for p53-dependent apoptosis. J Biol Chem. 2004 Nov 19;279(47):48930-40. [Content Brief]

[2]. Kyung-Tae Kim, et al. Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint. J Biol Chem. 2004 Sep 10;279(37):38597-602. [Content Brief]

[3]. S K Kurdistani, et al. Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage. Cancer Res. 1998 Oct 1;58(19):4439-44. [Content Brief]

[4]. Sushant K Kachhap, et al. The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin. PLoS One. 2007 Sep 5;2(9):e844. [Content Brief]

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