Protein phosphatase 1B

Definition:

Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

References:

[1]. Yanling Zhao, et al. PPM1B negatively regulates antiviral response via dephosphorylating TBK1. Cell Signal. 2012 Nov;24(11):2197-204. [Content Brief]

[2]. Wenjing Sun, et al. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Cell Signal. 2009 Jan;21(1):95-102. [Content Brief]

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