Protein YIPF5

Definition:

Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi.

References:

[1]. B L Tang, et al. A membrane protein enriched in endoplasmic reticulum exit sites interacts with COPII. J Biol Chem. 2001 Oct 26;276(43):40008-17. [Content Brief]

[2]. Elisa De Franco, et al. YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress. J Clin Invest. 2020 Dec 1;130(12):6338-6353. [Content Brief]

[3]. Catherine Z Chen, et al. Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor. Genetics. 2004 Dec;168(4):1827-41. [Content Brief]

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