Putative RNA-binding regulatory peptide

Definition:

Enhances binding of IGF2BP1 to N6-methyladenosine (m6A)-containing mRNAs, thereby contributing to increased mRNA stability. Also increases the interaction of IGF2BP1 with RNA stabilizers ELAVL1/HUR, MATR3 and PABPC1, and increases the interaction of RNA stabilizers ELAVL1/HUR, MATR3 and PABPC1 with m6A-containing mRNAs. Contributes to MYC stability by enhancing binding of IGF2BP1 to m6A-containing MYC mRNAs and increasing recruitment of RNA stabilizing proteins to m6A-containing MYC mRNAs.

References:

[1]. Song Zhu, et al. An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis. Nat Commun. 2020 Apr 3;11(1):1685. [Content Brief]

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