Rab11 family-interacting protein 3

Definition:

Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track).

References:

[1]. Richard J McKenney, et al. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014 Jul 18;345(6194):337-41. [Content Brief]

[2]. Conor P Horgan, et al. Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment. Traffic. 2007 Apr;8(4):414-30. [Content Brief]

[3]. Jian Jing, et al. Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton. Eur J Cell Biol. 2009 Jun;88(6):325-41. [Content Brief]

[4]. Gayle M Wilson, et al. The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Mol Biol Cell. 2005 Feb;16(2):849-60. [Content Brief]

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