Ras-GEF domain-containing family member 1B

Definition:

Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).

References:

[1]. Elif Yaman, et al. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. FEBS J. 2009 Aug;276(16):4607-16. [Content Brief]

[2]. Pelin Telkoparan, et al. Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the Ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis. PLoS One. 2013 Jul 19;8(7):e69289. [Content Brief]

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