Regenerating islet-derived protein 4

Definition:

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.

References:

[1]. Meng-Ru Ho, et al. Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. J Mol Biol. 2010 Oct 1;402(4):682-95. [Content Brief]

[2]. Meerit Kämäräinen, et al. RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa. Am J Pathol. 2003 Jul;163(1):11-20. [Content Brief]

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