Replication protein A 30 kDa subunit

Definition:

As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.

References:

[1]. Aaron C Mason, et al. Functions of alternative replication protein A in initiation and elongation. Biochemistry. 2010 Jul 20;49(28):5919-28. [Content Brief]

[2]. Aaron C Mason, et al. An alternative form of replication protein a prevents viral replication in vitro. J Biol Chem. 2009 Feb 20;284(8):5324-31. [Content Brief]

[3]. Michael G Kemp, et al. An alternative form of replication protein a expressed in normal human tissues supports DNA repair. J Biol Chem. 2010 Feb 12;285(7):4788-97. [Content Brief]

[4]. Stuart J Haring, et al. A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression. Nucleic Acids Res. 2010 Jan;38(3):846-58. [Content Brief]

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