Reticulon-4 receptor

Definition:

Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development.

References:

[1]. Sha Mi, et al. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci. 2004 Mar;7(3):221-8. [Content Brief]

[2]. Tadzia GrandPré, et al. Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature. 2002 May 30;417(6888):547-51. [Content Brief]

[3]. Zachary P Wills, et al. The nogo receptor family restricts synapse number in the developing hippocampus. Neuron. 2012 Feb 9;73(3):466-81. [Content Brief]

[4]. Betty P Liu, et al. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science. 2002 Aug 16;297(5584):1190-3. [Content Brief]

[5]. Kevin C Wang, et al. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature. 2002 Jun 27;417(6892):941-4. [Content Brief]

[6]. William A Barton, et al. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO J. 2003 Jul 1;22(13):3291-302. [Content Brief]

[7]. Nicole Teusch, et al. A high-content screening assay for the Nogo receptor based on cellular Rho activation. Assay Drug Dev Technol. 2006 Apr;4(2):133-41. [Content Brief]

[8]. Scott T Wong, et al. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat Neurosci. 2002 Dec;5(12):1302-8. [Content Brief]

[9]. H Kimura, et al. A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility. Transl Psychiatry. 2017 Aug 22;7(8):e1214. [Content Brief]

[10]. Stéphane Budel, et al. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. J Neurosci. 2008 Dec 3;28(49):13161-72. [Content Brief]

[11]. Gareth Williams, et al. Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem. 2008 Jun 13;283(24):16641-52. [Content Brief]

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