Rhomboid-related protein 2

Definition:

Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.

References:

[1]. S Urban, et al. Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell. 2001 Oct 19;107(2):173-82. [Content Brief]

[2]. John C Pascall, et al. Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2. Biochem Biophys Res Commun. 2004 Apr 23;317(1):244-52. [Content Brief]

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