Serine/threonine-protein kinase MRCK beta

Definition:

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).

References:

[1]. Ivan Tan, et al. A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. Cell. 2008 Oct 3;135(1):123-36. [Content Brief]

[2]. Timo Heikkila, et al. Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion. PLoS One. 2011;6(9):e24825. [Content Brief]

[3]. Ivan Tan, et al. Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase. FEBS Lett. 2011 May 6;585(9):1260-8. [Content Brief]

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