Serine/threonine-protein kinase Nek10

Definition:

Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport.

References:

[1]. Raghu R Chivukula, et al. A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nat Med. 2020 Feb;26(2):244-251. [Content Brief]

[2]. Larissa S Moniz, et al. Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation. Mol Cell Biol. 2011 Jan;31(1):30-42. [Content Brief]

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