Soluble calcium-activated nucleotidase 1

Definition:

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.

References:

[1]. Jiayin Dai, et al. Structure and protein design of a human platelet function inhibitor. Cell. 2004 Mar 5;116(5):649-59. [Content Brief]

[2]. Mathilde Nizon, et al. Further delineation of CANT1 phenotypic spectrum and demonstration of its role in proteoglycan synthesis. Hum Mutat. 2012 Aug;33(8):1261-6. [Content Brief]

[3]. Mingyan Yang, et al. Calcium-dependent dimerization of human soluble calcium activated nucleotidase: characterization of the dimer interface. J Biol Chem. 2006 Sep 22;281(38):28307-17. [Content Brief]

[4]. Thomas M Smith, et al. Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases. Arch Biochem Biophys. 2002 Oct 1;406(1):105-15. [Content Brief]

[5]. Mingyan Yang, et al. Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): identification of residues essential for enzyme activity and the Ca(2+)-induced conformational change. Biochemistry. 2004 Jul 20;43(28):9185-94. [Content Brief]

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