Speedy protein C

Definition:

Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.

References:

[1]. Silvana Mourón, et al. RINGO C is required to sustain the spindle-assembly checkpoint. J Cell Sci. 2010 Aug 1;123(Pt 15):2586-95. [Content Brief]

[2]. Aiyang Cheng, et al. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cell Cycle. 2005 Jan;4(1):155-65. [Content Brief]

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