Stomatin-like protein 1

Definition:

May play a role in cholesterol transfer to late endosomes. May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation.

References:

[1]. Wei Zhang, et al. The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ. PLoS One. 2012;7(10):e47736. [Content Brief]

[2]. Mario Mairhofer, et al. Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes. J Biol Chem. 2009 Oct 16;284(42):29218-29. [Content Brief]

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