Stromal interaction molecule 1

Definition:

Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch.

References:

[1]. S Wang, et al. STIM1 and SLC24A4 Are Critical for Enamel Maturation. J Dent Res. 2014 Jul;93(7 Suppl):94S-100S. [Content Brief]

[2]. Christine Peinelt, et al. Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol. 2006 Jul;8(7):771-3. [Content Brief]

[3]. Jen Liou, et al. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol. 2005 Jul 12;15(13):1235-41. [Content Brief]

[4]. Peter B Stathopulos, et al. STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry. Nat Commun. 2013;4:2963. [Content Brief]

[5]. Jonathan Soboloff, et al. Orai1 and STIM reconstitute store-operated calcium channel function. J Biol Chem. 2006 Jul 28;281(30):20661-20665. [Content Brief]

[6]. Jack Roos, et al. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 2005 May 9;169(3):435-45. [Content Brief]

[7]. Tsipi Ben-Kasus Nissim, et al. Mitochondria control store-operated Ca2+ entry through Na+ and redox signals. EMBO J. 2017 Mar 15;36(6):797-815. [Content Brief]

[8]. Ji Jing, et al. Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca²⁺ influx. Nat Cell Biol. 2015 Oct;17(10):1339-47. [Content Brief]

[9]. Raz Palty, et al. SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling. Cell. 2012 Apr 13;149(2):425-38. [Content Brief]

[10]. Chan Young Park, et al. STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell. 2009 Mar 6;136(5):876-90. [Content Brief]

[11]. Boyang Cui, et al. The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1. PLoS One. 2013 Sep 19;8(9):e74735. [Content Brief]

[12]. Peter B Stathopulos, et al. Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry. Cell. 2008 Oct 3;135(1):110-22. [Content Brief]

[13]. Maria A Spassova, et al. STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4040-5. [Content Brief]

[14]. Shenyuan L Zhang, et al. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature. 2005 Oct 6;437(7060):902-5. [Content Brief]

[15]. Johann Böhm, et al. Clinical, histological and genetic characterisation of patients with tubular aggregate myopathy caused by mutations in STIM1. J Med Genet. 2014 Dec;51(12):824-33. [Content Brief]

[16]. Vasyl Nesin, et al. Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4197-202. [Content Brief]

[17]. Jason C Mercer, et al. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem. 2006 Aug 25;281(34):24979-90. [Content Brief]

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