TATA element modulatory factor

Definition:

Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).

References:

[1]. Erez Perry, et al. TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3. Oncogene. 2004 Nov 25;23(55):8908-19. [Content Brief]

[2]. Junko Yamane, et al. Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic. Exp Cell Res. 2007 Oct 1;313(16):3472-85. [Content Brief]

[3]. J A Garcia, et al. Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor. Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9372-6. [Content Brief]

[4]. P W Hsiao, et al. Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells. J Biol Chem. 1999 Aug 6;274(32):22373-9. [Content Brief]

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