TBC1 domain family member 14

Definition:

Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy.

References:

[1]. Christopher A Lamb, et al. TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic. EMBO J. 2016 Feb 1;35(3):281-301. [Content Brief]

[2]. Andrea Longatti, et al. TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes. J Cell Biol. 2012 May 28;197(5):659-75. [Content Brief]

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