TBC1 domain family member 21

Definition:

Acts as a GTPase-activating protein for Rab family protein(s). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function (By similarity). Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail (By similarity). Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3 (By similarity). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity.

References:

[1]. Y-H Lin, et al. Identification and characterization of a novel Rab GTPase-activating protein in spermatids. Int J Androl. 2011 Oct;34(5 Pt 2):e358-67. [Content Brief]

[2]. Ying-Hung Lin, et al. RAB10 Interacts with the Male Germ Cell-Specific GTPase-Activating Protein during Mammalian Spermiogenesis. Int J Mol Sci. 2017 Jan 5;18(1):97. [Content Brief]

[3]. Koutaro Ishibashi, et al. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. Genes Cells. 2009 Jan;14(1):41-52. [Content Brief]

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