Terminal nucleotidyltransferase 5A

Definition:

Cytoplasmic non-canonical poly(A) RNA polymerase that catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and participates in the cytoplasmic polyadenylation. Polyadenylates mRNA encoding extracellular matrix constituents and other genes crucial for bone mineralization and during osteoblast mineralization, mainly focuses on ER-targeted mRNAs (By similarity).

References:

[1]. Olga Gewartowska, et al. Cytoplasmic polyadenylation by TENT5A is required for proper bone formation. Cell Rep. 2021 Apr 20;35(3):109015. [Content Brief]

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