Terminal nucleotidyltransferase 5C

Definition:

Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein.; (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.

References:

[1]. Seweryn Mroczek, et al. The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma. Nat Commun. 2017 Sep 20;8(1):619. [Content Brief]

[2]. John W Schoggins, et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011 Apr 28;472(7344):481-5. [Content Brief]

[3]. Jia-Li Hu, et al. FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Res. 2020 Mar 18;48(5):2733-2748. [Content Brief]

[4]. Hong Zhang, et al. Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C. Cancer Commun (Lond). 2021 Jul;41(7):615-630. [Content Brief]

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