Thimet oligopeptidase

Definition:

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).

References:

[1]. Eun Jeong Lim, et al. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. J Biol Chem. 2007 Mar 30;282(13):9722-9732. [Content Brief]

[2]. A Thompson, et al. Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide. Biochem Biophys Res Commun. 1995 Aug 4;213(1):66-73. [Content Brief]

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