Thioredoxin-dependent peroxide reductase, mitochondrial

Definition:

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength (By similarity).

References:

[1]. Adriana P Rebelo, et al. Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia. Brain. 2021 Jun 22;144(5):1467-1481. [Content Brief]

[2]. Megumi Masaki, et al. Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. Eur J Biochem. 2003 Jan;270(1):76-83. [Content Brief]

[3]. N Amy Yewdall, et al. Quaternary structure influences the peroxidase activity of peroxiredoxin 3. Biochem Biophys Res Commun. 2018 Mar 4;497(2):558-563. [Content Brief]

[4]. K Tsuji, et al. Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli. Biochem J. 1995 Apr 15;307 ( Pt 2)(Pt 2):377-81. [Content Brief]

[5]. Zhenbo Cao, et al. Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state. J Mol Biol. 2007 Sep 28;372(4):1022-1033. [Content Brief]

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