Thymic stromal lymphopoietin

Definition:

[Isoform 1]: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.; [Isoform 2]: May act as an antimicrobial peptide in the oral cavity and on the skin.

References:

[1]. P A Reche, et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol. 2001 Jul 1;167(1):336-43. [Content Brief]

[2]. H Quentmeier, et al. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. Leukemia. 2001 Aug;15(8):1286-92. [Content Brief]

[3]. L Bjerkan, et al. The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide. Mucosal Immunol. 2015 Jan;8(1):49-56. [Content Brief]

[4]. Zoulfia Allakhverdi, et al. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med. 2007 Feb 19;204(2):253-8. [Content Brief]

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