Trafficking kinesin-binding protein 1

Definition:

Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity).

References:

[1]. Gulcin Pekkurnaz, et al. Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell. 2014 Jul 3;158(1):54-68. [Content Brief]

[2]. Elizabeth Webber, et al. Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. J Mol Biol. 2008 Oct 10;382(3):638-51. [Content Brief]

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