Transcription factor Dp-1

Definition:

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.

References:

[1]. C L Wu, et al. In vivo association of E2F and DP family proteins. Mol Cell Biol. 1995 May;15(5):2536-46. [Content Brief]

[2]. K Helin, et al. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 1993 Oct;7(10):1850-61. [Content Brief]

[3]. Katrin Zaragoza, et al. Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Mol Cell Biol. 2010 May;30(9):2293-304. [Content Brief]

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