Transcription factor Dp family member 3

Definition:

Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.

References:

[1]. A Milton, et al. A functionally distinct member of the DP family of E2F subunits. Oncogene. 2006 May 25;25(22):3212-8. [Content Brief]

[2]. L Ingram, et al. E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit. Cell Death Differ. 2011 Jan;18(1):122-32. [Content Brief]

[3]. Huan Qiao, et al. Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. J Biol Chem. 2007 Jan 5;282(1):454-66. [Content Brief]

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