Transcription factor GATA-6

Definition:

Transcriptional activator. Regulates SEMA3C and PLXNA2. Involved in gene regulation specifically in the gastric epithelium. May regulate genes that protect epithelial cells from bacterial infection. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate.

References:

[1]. Yi-Qing Yang, et al. GATA6 loss-of-function mutation in atrial fibrillation. Eur J Med Genet. 2012 Oct;55(10):520-6. [Content Brief]

[2]. Nathan R Tucker, et al. Gain-of-function mutations in GATA6 lead to atrial fibrillation. Heart Rhythm. 2017 Feb;14(2):284-291. [Content Brief]

[3]. T Yoshida, et al. GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells. FEBS Lett. 1997 Sep 8;414(2):333-7. [Content Brief]

[4]. Jian Li, et al. Novel GATA6 loss-of-function mutation responsible for familial atrial fibrillation. Int J Mol Med. 2012 Oct;30(4):783-90. [Content Brief]

[5]. Bénédicte Oulès, et al. Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis. Nat Commun. 2020 Oct 20;11(1):5067. [Content Brief]

[6]. Kazuki Kodo, et al. GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13933-8. [Content Brief]

[7]. Michael Shapira, et al. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14086-91. [Content Brief]

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